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aldehyde oxidase การใช้

ประโยคมือถือ
  • Aldehyde oxidase is thought to have a significant impact on pharmacokinetics.
  • It is a selective inhibitor of aldehyde oxidase.
  • Ziprasidone is hepatically metabolized by aldehyde oxidase; minor metabolism occurs via cytochrome P450 3A4 ( CYP3A4 ).
  • Aldehyde oxidase ( ) catalyzes the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide.
  • A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by aldehyde oxidase.
  • MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase ( XDH ) and aldehyde oxidase ( AOX1 ), which is required for their enzymatic activities.
  • CPMP is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase / oxidase and aldehyde oxidase.
  • Aldehyde oxidase is very concentrated in the liver, where it oxidizes multiple aldehydes and nitrogenous heterocyclic compounds, such as anti-cancer and immunosuppressive drugs.
  • M2 and lenvatinib itself are oxidized by aldehyde oxidase ( AO ) to substances called M2'and M3', the main metabolites in the feces.
  • Lenvatinib is oxidized by cytochrome P450 enzymes ( CYP ), and further metabolized to the quinolinones M2'and M3'by aldehyde oxidase ( AO ).
  • Aldehyde oxidase is a member of the molybd-flavo protein family Higher primates, such as humans, have a single functioning AO gene ( AOX1 ), whereas rodents have four separate AOX genes.
  • Type II xanthinuria may result from a failure of the mechanism which inserts sulfur into the active sites of xanthine oxidase and aldehyde oxidase, a related enzyme with some overlapping activities ( such as conversion of allopurinol to oxypurinol ).
  • The eukaryotic molybdopterin binding domain is currently found in only five other human genes, xanthine dehydrogenase, sulfite oxidase ( mitochondrial precursor ), aldehyde oxidase, erythropoietin receptor precursor and the ATPbinding cassette, sub-family A, member 2 ( ABCA2 ).